Endocrine Abstracts

Introduction: Central obesity may be the cause of cardiometabolic disorders in adults. In children visceral adiposity is also associated with cardiometabolic risk factors. Waist circumference (WC) is a good surrogate marker of central adiposity, simple to measure. Paediatric studies indicate that within a particular Body mass Index (BMI) category, children with large WC have higher cardiovascular risk than those with smaller WC.Aim: To examine the relati...

IntroductionLimited evidence exists for hepatic fibrosis in Type 2 Diabetes (T2DM). NAFLD is an independent risk factor for incident diabetes with trends towards increased risk in women.MethodsWe conducted a cross-sectional, retrospective analysis in 438 women with T2DM.FIB-4 score was used to estimate extent of incidental finding of liver fibrosis.ResultsMean fib...

Background: Pituitary hyperplasia is a relatively common yet frequently overlooked condition which can occur in both physiological and pathological states. Pregnancy is one of the most common conditions associated with physiological pituitary enlargement.Case Presentation: 22-year-old normally fit and well lady presented to AMU (acute medicine unit) with a week history of headache and 10-month history of amenorrhoea following cessation of combined contra...

131I-metaiodobenzylguanide (MIBG) therapy, initially introduced in the 1980s, has emerged as a first-line to treatment of malignant phaeochromocytomas. Its other notable use has been in treating neuroblastomas occurring in childhood serving as an adjuvant prior to surgery or chemotherapy. An observed known late consequence of MIBG therapy is Primary ovarian failure (POI), characterised by menstrual irregularities over a period of 4 months associated with high Follicular stimul...

Introduction: Abiraterone acetate, potent selective irreversible inhibitor of CYP17A1, is increasingly used with prednisone to treat prostate cancer resistant to androgen deprivation therapy.Case Presentation: 64-year-old gentleman with BG of prostate cancer with widespread metastatic bone disease. He was on abiraterone since 2019. Admitted with generally unwell, aches/pains, headache, and dizziness. Euvolemic hyponatrem...

Introduction: Acute Colonic Pseudo-Obstruction (Ogilvie’s syndrome) is characterized by colonic distention in the absence of mechanical obstruction. Those without ischaemia/perforation is treated conservatively by withdrawing offending drugs, correcting electrolytes/underlying risk factors, neostigmine and colonic decompression.Case Presentation: 90-year-old frail lady from care home with HTN, CVA, and dementia, adm...

Background: Patient Safety Noticed issued by Welsh Government in June 2021 set out multiple action plans to be implemented by Welsh health boards to improve recognition and management of adrenal crisis. Hospitals were advised to review policies to ensure all patients at risk of Adrenal Crisis [(primary/secondary/tertiary adrenal insufficiency (AI)] were identified.Aim: In response, our hospital commenced a quality improv...

Introduction: EAS is an endocrine emergency requiring emergency diagnosis/treatment. Bronchial carcinoid is known to cause EAS and carcinoid syndrome (without liver involvement).Clinical features: 58-year-old lady with COPD and fibromyalgia referred as 2WW pathway with abdominal pain, diarrhoea, and weight loss. Investigated with CT-CAP: inflammatory looking 7mm lung nodule left upper lobe, enlarged left hilar, aorto-pul...

An 85-year-old woman attended the endocrine clinic with hypercalcaemia and raised PTH levels. Her background included breast cancer treated with bilateral mastectomy and hormone therapy 3 years previously, with no evidence of disease on imaging 2 years previously. On attendance, her clinical examination was unremarkable, with no palpable neck mass. Biochemical investigations showed: Adj Ca 3.12 mmol/l, PTH 45.0 pmol/l, PO4 0.94 mmol/l, ALP 119U/l, Alb 45g/l, 25-OH Vit D 15.7 n...

Introduction: Thyroid storm presents as multiorgan dysfunction. Diagnosis is purely clinical, and early diagnosis improves the outcomes.Case Presentation: 45-year-old lady without significant illness presented with breathlessness, productive cough, anxiety, and weight loss. Chest x-ray showed right pleural effusion and left consolidation. She was in fast AF with NT-proBNP >27000. initially treated as chest sepsis wit...